1. Guangye Li#, Guo Chen#, Guo-Hua Yuan#, Jia Wei#, Qingyang Ni, Jing Wu, Bei Yang, Li Yang*, Jia Chen*. Specific and efficient RNA A-to-I editing through cleavage of an ADAR inhibitor. Nat Biotechnol, 2025, doi: 10.1038/s41587-025-02591-2.
2. Yuhang Fan#, Wenchao Xu#, Bao-Qing Gao#, Huichao Qin, Xiaoyi Wu, Jia Wei, Qingyang Ni, Lina Zhou, Jiangchao Xiang, Jing Wu, Bei Yang, Li Yang, Jia Chen*. Leveraging base excision repair for efficient adenine base editing of mitochondrial DNA. Nat Biotechnol, 2025, doi: 10.1038/s41587-025-02608-w.
3. Qimingxing Chen#, Yan Chang#, Xiaoyan He, Yan Ding, Runyuan Wang, Ran Luo, Jialu Yuan, Jiabei Chen, Guisheng Zhong, Huiying Yang, Jia Chen*, Jianfeng Li*. Targeted Delivery of mRNA with Polymer–Lipid Nanoparticles for In Vivo Base Editing. ACS NANO. Feb 2025. 19(8): 7835–7850.
4. Chengfang Liu#, Sifan Cheng#, Junjie Zhu, Lina Zhou, Jia Chen*. A quick guide to evaluating prime editing efficiency in mammalian cells. Methods in Enzymology, 2025, doi.org/10.1016/bs.mie.2025.01.016
5. Jiangchao Xiang#, Wenchao Xu#, Jing Wu#, Yaxin Luo, Bei Yang*, Jia Chen*. Nucleoside deaminases: the key players in base editing toolkit. Biophys Rep, 2023, 9(6):325-337.
6. Wenyan Han#, Hou-Yuan Qiu#, Shangwu Sun#, Zhi-Can Fu#, Guo-Quan Wang#, Xiaowen Qian#, Lijie Wang, Xiaowen Zhai, Jia Wei, Yichuan Wang, Yi-Lin Guo, Guo-Hua Cao, Rui-Jin Ji, Yi-Zhou Zhang, Hongxia Ma, Hongsheng Wang, Mingli Zhao, Jing Wu, Lili Bi, Qiu-Bing Chen, Zifeng Li, Ling Yu, Xiaodun Mou, Hao Yin, Li Yang*, Jia Chen*, Bei Yang*, Ying Zhang*. Therapeutic base editing of the HBG promoter reactivates γ-globin expression with no detectable off-target mutations in beta-thalassemia HSCs. Cell Stem Cell, 2023, 30(12):1624-1639.e8.
7. Wenyan Han#, Baoqing Gao#, Junjie Zhu#, Zongxing He#, Jianfeng Li*, Li Yang*, Jia Chen*. Design and application of the transformer base editor in mammalian cells and mice. Nat Protoc, 2023, 18(11):3194-3228.
8. Wenwen Zhao#, Jifang Li#, Xiao Wang#, Wei Xu#, Baoqing Gao#, Jiangchao Xiang, Yaofeng Hou, Wei Liu, Jing Wu, Qilian Qi, Jia Wei, Xiaoyu Yang, Lu Lu*, Li Yang*, Jia Chen*, Bei Yang*. Prime editor-mediated functional reshaping of ACE2 prevents the entry of multiple human coronaviruses, including SARS-CoV-2variants. MedComm, 2023, 4:e356.
9. Li X#*, Zhou L#, Gao BQ#, Li G, Wang X, Wang Y, Wei J, Han W, Wang Z, Li J, Gao R, Zhu J, Xu W, Wu J, Yang B, Sun X*, Yang L*, Chen J*. 2022. Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure. Nat Commun, 13(1):1669.
10. Gao R#, Fu ZC#, Li X#, Wang Y#, Wei J, Li G, Wang L, Wu J, Huang X*, Yang L*, Chen J*. 2022. Genomic and Transcriptomic Analyses of Prime Editing Guide RNA-Independent Off-Target Effects by Prime Editors. CRISPR J, 5(2):276-293.
11. Wang J#, He Z#, Wang G#, Zhang R#, Duan J, Gao P, Lei X, Qiu H, Zhang C, Zhang Y, Yin H*. 2022. Efficient targeted insertion of large DNA fragments without DNA donors. Nat Methods, 19(3): 331-340.
12. Gao X#, Ma XK#, Li X, Li GW, Liu CX, Zhang J, Wang Y, Wei J, Chen J, Chen LL and Yang L*. 2022. Knockout of circRNAs by base editing back-splice sites of circularized exons. Genome Biol, 23: 16.
13. Wang L#, Xue W#, Zhang H#, Gao R#, Qiu H#, Wei J, Zhou L, Lei YN, Wu X, Li X, Liu C, Wu J, Chen Q, Ma H, Huang X, Cai C, Zhang Y, Yang B*, Yin H*, Yang L* and Chen J*. 2021. Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations. Nat Cell Biol, 23(5): 552-563.
14. Wang X#, Ding C#, Yu W#, Wang Y#, He S#, Yang B#, Xiong YC, Wei J, Li J, Liang J, Lu Z, Zhu W, Wu J, Zhou Z, Huang X, Liu Z*, Yang L* and Chen J*. 2020. Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response. Cell Rep, 31(9): 107723.
15. Song CQ#, Jiang T#, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR*, Yin H*, and Xue W*. 2020. Adenine base editing in an adult mouse model of tyrosinaemia. Nat Biomed Eng, 4: 125-130.
16. Wang Y#, Gao R#, Wu J#, Xiong YC, Wei J, Zhang S, Yang B, Chen J* and Yang Y*. 2019. Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs. Genome Biol, 20(1): 218.
17. Wang X#, Li J#, Wang Y#, Yang B#, Wei J#, Wu J, Wang R, Huang X*, Chen J* and Yang L*. 2018. Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion. Nat Biotechnol, 36(10): 946-949.
18. Li X#, Wang Y#, Liu Y#, Yang B#, Wang X, Wei J, Lu Z, Zhang Y, Wu J, Huang X*, Yang L* and Chen J*. 2018. Base editing with a Cpf1-cytidine deaminase fusion. Nat Biotechnol, 36(4): 324-327.
19. Xiang JF#, Yang Q#, Liu CX#, Wu M, Chen LL* and Yang L*. 2018. N(6)-Methyladenosines Modulate A-to-I RNA Editing. Mol Cell, 69(1): 126-135 e126.
20. Lei L#, Chen H#, Xue W#, Yang B#, Hu B#, Wei J, Wang L, Cui Y, Li W, Wang J, Yan L, Shang W, Gao J, Sha J, Zhuang M, Huang X, Shen B*, Yang L* and Chen J*. 2018. APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks. Nat Struct Mol Biol, 25(1): 45-52.
21. Yin H#, Song CQ#, Suresh S, Kwan SY, Wu Q, Walsh S, Ding J, Bogorad RL, Zhu LJ, Wolfe SA, Koteliansky V, Xue W*, Langer R* and Anderson DG*. 2018. Partial DNA-guided Cas9 enables genome editing with reduced off-target activity. Nat Chem Biol, 14(3):311-316.
22. Wang L#, Xue W#, Yan L#, Li X, Wei J, Chen M, Wu J, Yang B*, Yang L* and Chen J*. 2017. Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor. Cell Res, 27(10): 1289-1292.
23. Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, Zatsepin T, Koteliansky V, Wolfe SA, Xue W, Langer R and Anderson DG*. 2017. Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing. Nat Biotechnol, 35(12):1179-1187.
24. Yin H, Song CQ, Dorkin JR, Zhu L, Li Y, Wu Q, Park A, Yang J, Suresh S, Bizhanova A, Gupta A, Bolukbasi M, Walsh S, Bogorad R, Gao G, Weng Z, Dong Y, Koteliansky V, Wolfe S, Langer R, Xue W* and Anderson DG*. 2016. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo. Nat Biotechnol, 34(3):328-33.
25. Zhang XO#, Wang HB#, Zhang Y, Lu X, Chen LL* and Yang L*. 2014. Complementary sequence-mediated exon circularization. Cell, 159(1): 134-147.
26. Yin H#, Xue W#, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T and Anderson DG*. 2014. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nat Biotechnol, 32(6): 551-553.
27. Xue W#, Chen S#, Yin H#, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA and Jacks T*. 2014. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature, 514(7522): 380-384.
28. Chen J, Miller BF and Furano AV*. 2014. Repair of naturally occurring mismatches can induce mutations in flanking DNA. Elife, 3: e02001.
1. Jin-Soo Kim*, Jia Chen*. Base editing of organellar DNA with programmable deaminases. Nat Rev Mol Cell Biol, 2024, 25(1):34-45.
2. Li Yang*, Jia Chen*. Expanding genome editing scopes with artificial intelligence. Sci Bull, 2023, 68(23):2881-2883.
3. Gao C* and Chen J*. 2021. CRISPR Adventures in China. CRISPR J, 4(3): 304-306.
4. Chen Q, Zhang Y* and Yin H*. 2021. Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing. Adv Drug Deliv Rev, 168: 246–258.
5. Yang L* and Chen J*. 2020. A Tale of Two Moieties: Rapidly Evolving CRISPR/Cas-Based Genome Editing. Trends Biochem Sci, 45(10): 874-888.
6. Yang L*, Yang B* and Chen J*. 2019. One Prime for All Editing. Cell, 179(7): 1448-1450.
7. Chen J*, Yang B* and Yang L*. 2019. To BE or not to BE, that is the question. Nature Biotechnology, 37(5): 520-522.
8. Yang B*, Yang L* and Chen J*. 2019. Development and Application of Base Editors. CRISPR J, 2(2): 91-104.
9. Zhang HX, Zhang Y* and Yin H*. 2019. Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9. Mol Ther, 27(4): 735–746.
10. Yin H*, Xue W* and Anderson DG*. 2019. CRISPR-Cas: a tool for cancer research and therapeutics. Nat Rev Clin Oncol, 16(5): 281-295.
11. Pawluk A*, Chen J, Ji W and Mali P. 2018. The Future of Genome Editing. Cell, 173(6): 1311-1313.
12. Yang B*, Li X, Lei L and Chen J*. 2017. APOBEC: From mutator to editor. J Genet Genomics, 44(9): 423-437.
13. Yin H, Kauffman KJ and Anderson DG*. 2017. Delivery technologies for genome editing. Nat Rev Drug Discov, 16(6): 387-399.
14. Yin H, Kanasty RL, Eltoukhy AA, Vegas AJ, Dorkin JR and Anderson DG*. 2014. Non-viral vectors for gene-based therapy. Nat Rev Genet, 15(8): 541-555.
(#: co-first author, *: corresponding author)